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Updated: Aug 25, 2025
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
Published on: June 21, 2018
Natural products targeting human lactate dehydrogenases for cancer therapy: A mini review
Huankai Yao1, Feng Yang2, Yan Li1
1Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Abstract:
Reprogramming cancer metabolism has become the hallmark of cancer progression. As the key enzyme catalyzing the conversion of pyruvate to lactate in aerobic glycolysis of cancer cells, human lactate dehydrogenase (LDH) has been a promising target in the discovery of anticancer agents. Natural products are important sources of new drugs. Up to now, some natural compounds have been reported with the activity to target LDH. To give more information on the development of LDH inhibitors and application of natural products, herein, we reviewed the natural compounds with inhibition of LDH from diverse structures and discussed the future direction of the discovery of natural LDH inhibitors for cancer therapy.
Insights
Natural products offer potential anticancer agents by inhibiting human lactate dehydrogenase (LDH), a key enzyme in cancer cell metabolism. This review explores diverse natural compounds targeting LDH for future cancer therapy development.
Area of Science:
- Biochemistry
- Oncology
- Pharmacology
Background:
- Cancer cells exhibit altered metabolism, a hallmark of tumor progression.
- Human lactate dehydrogenase (LDH) is crucial for aerobic glycolysis in cancer cells, making it a therapeutic target.
- Natural products are a rich source of novel drug candidates.
Purpose of the Study:
- To review natural compounds that inhibit human lactate dehydrogenase (LDH).
- To discuss the potential of natural LDH inhibitors in cancer therapy.
- To explore future directions in discovering natural LDH inhibitors.
Main Methods:
- Literature review of natural compounds targeting LDH.
- Analysis of diverse chemical structures of identified inhibitors.
- Discussion of therapeutic implications and future research avenues.
Main Results:
- Several natural compounds with LDH inhibitory activity have been identified.
- These compounds originate from diverse structural classes.
- The review synthesizes current knowledge on natural LDH inhibitors.
Conclusions:
- Natural products represent a promising avenue for developing novel anticancer agents targeting LDH.
- Further research into natural LDH inhibitors could lead to new cancer therapies.
- Understanding the structure-activity relationships of these compounds is key for future drug discovery.
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