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The Continuing Ophthalmic Challenge of Bartonella henselae

Daniel M Albert1, Ali R Salman2, Kevin L Winthrop1

  • 1Casey Eye Institute, Portland, Oregon.

Ophthalmology Science
|October 17, 2022
PubMed

Insights

Bartonella henselae eye infections, linked to cat scratch disease (CSD), have a complex history. Accurate incidence and prevalence data are lacking due to diagnostic inconsistencies, hindering public health efforts.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Epidemiology

Background:

  • Bartonella henselae causes ocular infections, including Parinaud's oculoglandular syndrome and Leber's stellate retinitis.
  • These conditions are historically linked to cat scratch disease (CSD).
  • Ocular Bartonella henselae infections remain a significant public health concern.

Purpose of the Study:

  • To elucidate the history and epidemiology of Bartonella henselae eye infections.
  • To understand the relationship between ocular Bartonella henselae and cat scratch disease (CSD).
  • To evaluate Bartonella henselae infection as a public health threat.

Main Methods:

  • Literature review on Bartonella henselae eye infections and CSD.
  • Attempted incidence and prevalence calculation using the Rochester Epidemiology Project database.

Main Results:

  • Identified ocular manifestations as subtypes of CSD, a century after initial descriptions.
  • Highlighted that accurate incidence and prevalence data are undetermined.
  • Found diagnostic terminology and coding inconsistencies as a major obstacle in data collection.

Conclusions:

  • Ophthalmologists can leverage modern diagnostics for precision medicine approaches to Bartonella henselae eye infections.
  • Increased awareness, standardized terminology, and enhanced clinical/research efforts are necessary.
  • Further investigation is required to address unanswered questions regarding these infections.
Abstract

Keywords:
AFIP, Armed Forces Institute of PathologyBartonella henselaeCSD, cat scratch diseaseICD-10, International Classification of Diseases 10th EditionPOGS, Parinaud’s oculoglandular syndromeParinaud’s oculoglandular syndromecat scratch diseaseprecision medicineserologic testing

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