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Rhupus Syndrome: A Diagnostic Dilemma
Susmita Upadhyaya1, Mayank Agarwal1, Ashutosh Upadhyaya2
1Internal Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Cureus
|October 17, 2022
Summary
Rhupus syndrome, a rare autoimmune condition, involves both rheumatoid arthritis and systemic lupus erythematosus. This case highlights erosive polyarthritis preceding lupus symptoms in a young woman.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Rhupus syndrome is a rare autoimmune disorder characterized by the coexistence of rheumatoid arthritis and systemic lupus erythematosus (SLE).
- It presents with symmetrical erosive polyarthritis, deformities, and SLE-specific clinical and serological features.
- Neurological and hematological involvement can complicate prognosis and impact patient quality of life.
Observation:
- This report details a case of a young female patient.
- The patient experienced symmetric, bilateral, erosive polyarthritis for 1.5 years before developing SLE symptoms.
- SLE manifestations appeared approximately six months after the onset of polyarthritis.
Findings:
- The case illustrates a distinct temporal sequence in the development of Rhupus syndrome.
- Early polyarthritis preceded the diagnosis of systemic lupus erythematosus in this patient.
- Rhupus patients exhibit less renal involvement compared to SLE patients.
Implications:
- Understanding the varied presentations of Rhupus syndrome is crucial for timely diagnosis and management.
- This case emphasizes the importance of recognizing overlapping autoimmune conditions.
- Further research into the pathogenesis and clinical course of Rhupus syndrome is warranted.
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