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Updated: Aug 25, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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Transient decrease in sound tolerance levels following hearing deprivation in normal-hearing subjects.

Eleazar Graterón1, Tricia Scaglione2, Shriya Airen2

  • 1Fundación Venezolana de Otología, Clinical Research Group, Venezuela.

Journal of Otology
|October 17, 2022
PubMed
Summary
This summary is machine-generated.

Daytime hearing deprivation reduces sound tolerance more than nighttime deprivation in healthy adults. This suggests increased central gain in the awake cortex may explain daytime hypersensitivity.

Keywords:
ACTH, adrenocorticotropic hormoneBMI, body mass indexCNS, central nervous systemCentral gainDPOAE, distortion products otoacoustic emissionsDSM-V, Diagnostic and Statistical Manual of Mental DisordersFVO, Venezuelan Foundation of OtologyGABA, ϒ-aminobutyric acidGABA-R, ϒ-aminobutyric acid receptorsHearing deprivationHyperacusisNBN, narrow band noiseNRR, noise reduction ratioOHC, outer hair cellsOSHA, Occupational Safety and Health AdministrationSRT, stapedial reflex thresholdULL, uncomfortable loudness levelr.p.m., revolutions per minute

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Area of Science:

  • Audiology
  • Chronobiology
  • Neuroscience

Background:

  • Circadian rhythms significantly influence physiological functions, including auditory processing.
  • Temporal hearing deprivation can alter sound sensitivity, but its circadian modulation is not well understood.

Purpose of the Study:

  • To investigate the circadian influence on sound sensitivity following temporary hearing deprivation in healthy individuals.

Main Methods:

  • Thirty healthy volunteers underwent bilateral earplugging and completed audiological tests, including pure tone audiometry (PTA), stapedial reflex thresholds (SRT), distortion products otoacoustic emissions (DPOAEs), and uncomfortable loudness levels (ULLs).
  • Participants were divided into two groups based on the timing of the hearing deprivation session: Group A (daytime) and Group B (nighttime).
  • Serum cortisol and urinary cortisol levels were measured to assess circadian markers.

Main Results:

  • Uncomfortable loudness levels (ULLs) were significantly lower in Group A (daytime deprivation) compared to Group B (nighttime deprivation).
  • A stapedial reflex threshold (SRT) shift was observed in Group A, while a shift in DPOAE input/output was noted in Group B.
  • No significant difference in PTA was found between the groups.

Conclusions:

  • Reduced loudness tolerance occurs during daytime hearing deprivation, contrasting with nighttime deprivation.
  • This daytime hypersensitivity may be attributed to increased central gain within the awake auditory cortex.