Related Experiment Video

Updated: Aug 25, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K

Circadian clock-mediated nuclear receptors in cancer

Ya Niu1,2, Shuang Tang1,2,3

  • 1Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.

Journal of Cellular Physiology
|October 17, 2022
PubMed

Insights

The circadian system regulates daily bodily functions. Disruptions to this internal clock are linked to cancer, and understanding clock-related nuclear receptors is key for developing new cancer treatments.

Area of Science:

  • * Chronobiology and Cancer Biology
  • * Molecular Mechanisms of Cancer Progression

Background:

  • * The circadian system governs daily physiological rhythms, crucial for adaptation.
  • * Circadian disruption is associated with increased cancer risk and progression.
  • * Mechanisms linking circadian clock dysfunction to cancer remain largely unknown.

Purpose of the Study:

  • * To review recent advances in clock-related nuclear receptors in cancer biology.
  • * To elucidate the mechanistic insights into how nuclear receptors and the circadian clock interact.
  • * To explore the role of these interactions in tumorigenesis and cancer treatment.

Main Methods:

  • * Literature review of recent studies on circadian clock components and nuclear receptors in cancer.
  • * Analysis of mechanistic pathways involving nuclear receptors in cancer processes.
  • * Synthesis of current understanding of circadian regulation in cancer biology and therapy.

Main Results:

  • * Several nuclear receptors involved in circadian rhythm regulation also play significant roles in cancer.
  • * These nuclear receptors mediate key cancer processes, including tumorigenesis.
  • * Understanding the interplay between clock genes and nuclear receptors offers therapeutic potential.

Conclusions:

  • * Clock-related nuclear receptors are critical mediators in cancer development and progression.
  • * Elucidating their mechanisms can reveal new strategies for cancer prevention.
  • * Targeting these pathways may enhance the efficacy of chronochemotherapy and improve patient outcomes.
Keywords:
cancercircadian rhythmclocknuclear receptors

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.5K

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.5K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
35.4K
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.6K
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.9K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K