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D-galactose-induced cardiac ageing: A review of model establishment and potential interventions
Sui-Sui Wang1,2, Xu Zhang1,2, Ze-Zhi Ke1,2
1Guangdong Engineering Research Center for Light and Health, Guangzhou Higher Education Mega Center, Guangdong Pharmaceutical University, Guangzhou, China.
Insights
This review summarizes the D-galactose-induced cardiac ageing model, a cost-effective tool for studying cardiovascular disease (CVD) in aging hearts. It highlights recent therapeutic interventions for age-related heart conditions.
Area of Science:
- Gerontology
- Cardiology
- Pharmacology
Background:
- Cardiovascular disease (CVD) presents a significant global health challenge, particularly in aging populations.
- Understanding the mechanisms of CVD in aging hearts is crucial for developing effective interventions.
- The D-galactose-induced cardiac ageing model offers a practical approach to studying age-related cardiovascular changes.
Purpose of the Study:
- To review recent advancements in the D-galactose-induced cardiac ageing model.
- To summarize potential therapeutic interventions for age-related cardiac dysfunction.
- To provide a comprehensive overview of in vivo and in vitro studies using this model.
Main Methods:
- Comprehensive literature review of studies utilizing the D-galactose-induced cardiac ageing model.
- Analysis of research on both in vivo and in vitro experimental setups.
- Synthesis of findings related to pathogenesis and therapeutic strategies.
Main Results:
- The D-galactose model is characterized by low mortality, short experimental duration, and cost-effectiveness.
- Recent research has identified various potential therapeutic interventions targeting D-galactose-induced cardiac ageing.
- Studies demonstrate the model's utility in exploring the pathophysiology of age-related cardiac decline.
Conclusions:
- The D-galactose-induced cardiac ageing model is a valuable tool for investigating age-related cardiovascular diseases.
- Further research into therapeutic interventions is warranted to combat CVD in aging hearts.
- This review serves as a reference for future studies on geriatric cardiology.
Abstract:
Cardiovascular disease (CVD) is highly prevalent in an ageing society. The increased incidence and mortality rates of CVD are global issues endangering human health. There is an urgent requirement for understanding the aetiology and pathogenesis of CVD and developing possible interventions for preventing CVD in ageing hearts. It is necessary to select appropriate models and treatment methods. The D-galactose-induced cardiac ageing model possesses the advantages of low mortality, short time and low cost and has been increasingly used in the study of cardiovascular diseases in recent years. Therefore, understanding the latest progress in D-galactose-induced cardiac ageing is valuable. This review highlights the recent progress and potential therapeutic interventions used in D-galactose-induced cardiac ageing in recent years by providing a comprehensive summary of D-galactose-induced cardiac ageing in vivo and in vitro. This review may serve as reference literature for future research on age-related heart diseases.
