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Related Concept Videos

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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Cannabidiol Safety Data: A Systematic Mapping Study.

Rayetta G Henderson1, Kara S Franke2, Lauren E Payne2

  • 1ToxStrategies, Inc., Wilmington, North Carolina, USA.

Cannabis and Cannabinoid Research
|October 17, 2022
PubMed
Summary
This summary is machine-generated.

A systematic map of cannabidiol (CBD) safety studies reveals significant data gaps, particularly in reproductive and developmental toxicity. Further research is crucial for establishing safe consumer intake levels and health benchmarks for CBD.

Keywords:
CBDcannabidiolhempsafetysystematic mapping

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Area of Science:

  • Pharmacology and Toxicology
  • Public Health
  • Systematic Reviews

Background:

  • Determining safe cannabidiol (CBD) intake levels requires robust assessment of potential adverse outcomes.
  • Existing peer-reviewed literature on CBD safety needs systematic evaluation to identify knowledge gaps.

Purpose of the Study:

  • To create the first systematic map of safety-related information for CBD in the peer-reviewed literature.
  • To identify knowledge gaps and inform future health-based benchmark development for CBD.

Main Methods:

  • Conducted a comprehensive literature search yielding 4186 unique titles and abstracts up to 2020.
  • Screened studies for health outcomes following CBD exposure using DistillerSR.
  • Categorized 1001 studies focusing on CBD administered alone.

Main Results:

  • Neurological outcomes were most frequently studied (532), followed by carcinogenic (129) and pharmacokinetic (118) outcomes.
  • Neurological and developmental/reproductive outcomes showed the most reported adverse events.
  • Significant data gaps exist in reproductive and developmental toxicity for CBD.

Conclusions:

  • Reproductive and developmental toxicity represents a critical data gap requiring guideline-compliant studies.
  • Immune outcomes are an emerging area for CBD research.
  • This systematic map serves as a baseline for future research on the safe use of CBD.