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Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development

Vivek Agrahari¹, Sharon M Anderson¹, M Melissa Peet¹

¹CONRAD, Eastern Virginia Medical School, Norfolk, VA, USA.

Expert Opinion on Drug Delivery

|October 17, 2022

Summary

Long-acting (LA) antiretrovirals (ARVs) offer a promising solution to improve adherence for HIV pre-exposure prophylaxis (PrEP). Advances in drug delivery systems aim to overcome challenges for effective HIV prevention.

Area of Science:

HIV Prevention Research
Pharmacology
Drug Delivery Systems

Background:

Suboptimal adherence to daily oral pre-exposure prophylaxis (PrEP) is a significant barrier to effective HIV prevention.
Long-acting (LA) antiretrovirals (ARVs) and advanced drug delivery systems (DDS) offer potential solutions to improve adherence by extending dosing intervals.

Conclusions:

Next-generation LA PrEP holds significant potential to reduce the HIV pandemic if developed to be safe, affordable, effective, and widely accepted.
Proactive consideration of product design and testing is crucial for successful implementation, especially in resource-limited settings.

Keywords:

Adherence HIV prevention antiretroviral drug delivery system implants injectable long-acting microbicide nanoformulations prodrug

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