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Updated: Aug 25, 2025
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Doxorubicin loaded hydrogel microparticles from microfluidics for local injection therapy of tumors
Xiao Ma1, Caihong Yang1, Ruirui Zhang1
1National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, Guangxi, 530021, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health); Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Abstract:
Doxorubicin (DOX) is a powerful chemotherapy drug for cancer treatment, especially in patients with advanced cancer. However, clinical use of DOX remains challenging due to its widespread drug resistance and severe cardiotoxicity. Here, we developed a novel DOX-loaded natural hydrogel microparticle by using microfluidic electrospray technology. The designed carboxymethyl cellulose-based hydrogel microparticles were cross-linked by iron ions and showed a sustained drug release. The animal experiments revealed that DOX-loaded microparticles had good biocompatibility when locally injected into tumor-bearing mice, and could enhance the effect of chemotherapy and effectively inhibit tumor growth without obvious toxicity. These features indicated that the natural biomass-based hydrogel microparticles are highly promising for chemotherapy drugs delivery and provide a platform for local therapy.
