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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Hydroxypropyl-β-cyclodextrin-based solid dispersed granules: A prospective alternative to conventional solid
Jung Suk Kim1, Fakhar Ud Din2, Yoo Jin Choi1
1College of Pharmacy, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan 15588, South Korea.
International Journal of Pharmaceutics
|October 17, 2022
Summary
Hydroxypropyl-β-cyclodextrin (HP-β-CD)-based solid dispersed granules offer improved powder properties and comparable oral bioavailability to solid dispersions for poorly soluble drugs like dexibuprofen.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Poorly water-soluble drugs present challenges in oral administration.
- Solid dispersion is a common technique to enhance drug solubility and bioavailability.
- Developing improved formulations is crucial for effective drug delivery.
Purpose of the Study:
- To develop hydroxypropyl-β-cyclodextrin (HP-β-CD)-based solid dispersed granules.
- To evaluate these granules as a superior alternative to traditional solid dispersion.
- To compare their efficacy in improving solubility, dissolution, and oral bioavailability of dexibuprofen.
Main Methods:
- Fabrication of solid dispersion (drug/HP-β-CD/Tween80) using a spray-dryer.
- Fabrication of solid dispersed granules (drug/HP-β-CD/Tween80/Microcrystalline cellulose) using a fluid bed granulator.
- Comparative analysis of powder properties, solubility, dissolution, and oral bioavailability.
Main Results:
- HP-β-CD-based solid dispersed granules significantly enhanced dexibuprofen solubility and dissolution.
- Oral bioavailability of dexibuprofen was maximized to the same extent as solid dispersion.
- Solid dispersed granules showed considerable improvements in powder and tablet properties compared to solid dispersion.
Conclusions:
- HP-β-CD-based solid dispersed granules represent a promising advancement over traditional solid dispersions.
- This formulation offers enhanced drug solubility, dissolution, and bioavailability with improved physical properties.
- Solid dispersed granules are a prospective alternative for formulating poorly water-soluble drugs.
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