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Updated: Aug 25, 2025
08:31
Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
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Freehand scanning photoacoustic microscopy with simultaneous localization and mapping
Jiangbo Chen1, Yachao Zhang1, Jingyi Zhu1
1Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon, Hong Kong Special Administrative Region of China.
Photoacoustics
|October 18, 2022
Summary
Freehand scanning photoacoustic microscopy (FS-PAM) overcomes limitations of traditional methods. This new technique provides flexible, high-speed 3D imaging for diverse biomedical applications.
Area of Science:
- Biomedical Optics
- Photoacoustic Imaging
- Medical Technology
Background:
- Optical-resolution photoacoustic microscopy (OR-PAM) provides high-resolution, label-free imaging.
- Existing OR-PAM systems face limitations: small field of view, bulky probes, and slow imaging speeds.
Purpose of the Study:
- To develop a novel freehand scanning photoacoustic microscopy (FS-PAM) system.
- To overcome the technical barriers of OR-PAM for enhanced biomedical imaging.
Main Methods:
- Development of a compact, handheld photoacoustic probe for flexible 3D imaging.
- Implementation of high-speed scanning enabling video-rate imaging and simultaneous localization and mapping (SLAM).
Main Results:
- Demonstrated fast in vivo imaging of mouse organs and human oral mucosa.
- Achieved reduced motion artifacts due to high imaging speed.
- Successfully localized small lesions in large brain regions.
Conclusions:
- FS-PAM offers a flexible, high-speed imaging solution with an extendable field of view.
- This technology enhances the applicability of photoacoustic microscopy in biomedical research and clinical settings.
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