Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

91
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
91
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

64
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
64
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.1K
Mutations in Microorganisms01:18

Mutations in Microorganisms

57
Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
57

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PCOSFusion: a hybrid HOG-LBP feature-based approach for PCOS classification using StackPCOS and StackBoostPCOS.

Scientific reports·2026
Same author

Knowledge enhanced framework for managing electricity generation and consumption in micro smart grids using Heronian mean MCDM approach.

Scientific reports·2026
Same author

Probiotic-Induced Gut Microbiota Modulation: A Comparative Analysis Using 16S rRNA V3-V4 and Targeted Sequencing.

Microorganisms·2026
Same author

Development of a Facemask System for Measuring Enteric Methane and Carbon Dioxide Production in Lactating Cows.

Animals : an open access journal from MDPI·2026
Same author

Immunoinformatics-Based Design of a Multiple-Epitope Vaccine Against IHNV.

Marine biotechnology (New York, N.Y.)·2026
Same author

Barriers to Palliative Care Integration for Children With Cancer Across Asia Pacific.

JCO global oncology·2026
Same journal

Development of CypriSSR: a genome-wide, chromosome-level microsatellite database for multiple cyprinidae species.

Database : the journal of biological databases and curation·2026
Same journal

KitBase Expanded: An Integrated Genomic and Phenotypic Resource for 3,268 Fast-Neutron-Irradiated Rice Mutants.

Database : the journal of biological databases and curation·2026
Same journal

PhaLP 2.0: extending the community-oriented phage lysin database with a SUBLYME pipeline for metagenomic discovery.

Database : the journal of biological databases and curation·2026
Same journal

A similarity metric, rubric, and unified hierarchy for biomedical publication types and study designs.

Database : the journal of biological databases and curation·2026
Same journal

GUTAID: a curated database linking gut microbial antigens to autoimmune mechanisms.

Database : the journal of biological databases and curation·2026
Same journal

Rosetta Statements: simplifying FAIR knowledge graph construction with a user-centred approach.

Database : the journal of biological databases and curation·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.8K

PharmaKoVariome database for supporting genetic testing.

Jungeun Kim1, Jae-Pil Choi1, Min Sun Kim1

  • 1Personal Genomics Institute (PGI), Genome Research Foundation (GRF), Cheongju 28190, Republic of Korea.

Database : the Journal of Biological Databases and Curation
|October 18, 2022
PubMed
Summary
This summary is machine-generated.

The PharmaKoVariome database offers ethnic-specific genetic variant data for pharmacogenomics (PGx), supporting precision medicine and drug development. It highlights Asian-specific variants, crucial for safe drug prescriptions in diverse populations.

More Related Videos

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.8K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.9K

Related Experiment Videos

Last Updated: Aug 25, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.8K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.8K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.9K

Area of Science:

  • Genetics
  • Pharmacology
  • Bioinformatics

Background:

  • Pharmacogenomics (PGx) enables precision medicine through genotype information.
  • Existing PGx data predominantly reflects European and American populations, limiting global applicability.
  • There is a need for ethnic-specific data on drug-gene interactions and allele frequencies.

Purpose of the Study:

  • To develop the PharmaKoVariome database, consolidating comprehensive drug-gene interaction and disease data.
  • To precompute ethnic-specific single-nucleotide variants for drug-target genes.
  • To facilitate genetic testing and drug development tailored to diverse ethnic groups, particularly in Asia.

Main Methods:

  • Consolidated data from public databases, including diseases, drugs, and drug-target genes.
  • Stored information on 2507 diseases, 11,459 drugs, and 61,627 drug-target or druggable genes.
  • Precomputed ethnic-specific variants for approximately 120 million single-nucleotide variants.

Main Results:

  • The database supports searches by gene symbol, drug name, disease, and rsID.
  • Statistical analysis of ethnic variation frequencies (odds ratio, P-values) is available.
  • Identified Korean-enriched variants in CYP2B6 and CYP2D6, including a drug-metabolism-impaired variant (rs1065852).
  • Found that 4-6% of North and East Asians carry risk factors for CYP2D6-metabolized drugs.

Conclusions:

  • PharmaKoVariome is a valuable resource for pharmaceutical and diagnostic companies.
  • It supports the development of diagnostic technologies for the Asian pharmacogenomics industry.
  • Enhances the application of precision medicine by providing ethnic-specific PGx information.