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Brainnetome atlas of preadolescent children based on anatomical connectivity profiles

Wen Li1,2, Lingzhong Fan1,2,3,4, Weiyang Shi1,2,3

  • 1Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 95 Zhongguancun East Road, Beijing 100190, China.

Cerebral Cortex (New York, N.Y. : 1991)
|October 18, 2022
PubMed

Insights

Researchers developed a new brain atlas for preadolescent children using longitudinal data. This Child Brainnetome Atlas offers precise, age-specific mapping crucial for understanding cognitive development in youth.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Preadolescent brain development involves dynamic changes in cerebral thickness, curvature, and myelination.
  • These changes drive the maturation of higher cognitive functions.
  • Existing brain atlases often do not accurately reflect the unique topological patterns of developing pediatric brains.

Purpose of the Study:

  • To create an age-specific brain atlas for preadolescent children.
  • To provide a more accurate tool for studying normal child brain development.
  • To establish a topologically consistent reference for pediatric neuroscience research.

Main Methods:

  • Utilized longitudinal neuroimaging data.
  • Constructed a novel brain atlas tailored for the preadolescent period.
  • Included 188 cortical and 36 subcortical subregions.
  • Cross-validated the atlas for precision and reliability.

Main Results:

  • Developed the human Child Brainnetome Atlas, a period-specific brain map for preadolescents.
  • The atlas comprises 188 cortical and 36 subcortical regions.
  • Identified and illustrated topological differences between child and adult brain atlases.

Conclusions:

  • The Child Brainnetome Atlas is a precise and validated tool for preadolescent brain research.
  • Age-specific brain mapping is essential for understanding pediatric cognitive development.
  • This atlas provides a crucial reference for future studies on child and adolescent brain development.

Keywords:
Brainnetome atlasanatomical connectivitydevelopmentdiffusion magnetic resonance imagingpreadolescent child

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