High-throughput and directed microparticle manipulation in complex-shaped maze chambers based on travelling surface...

Area of Science:

• Microfluidics
• Acoustic manipulation
• Biotechnology

Background:

• Automated microparticle manipulation is crucial for pharmaceutical microfluidics.
• Efficient actuation in complex chamber structures remains a challenge.

Purpose of the Study:

• To present a novel traveling surface acoustic wave (TSAW)-based device for automated microparticle manipulation.
• To demonstrate high-throughput maze-solving capabilities in complex-shaped chambers.

Main Methods:

• Utilized TSAWs to generate localized acoustic streaming for microparticle trapping and movement.
• Employed numerical modeling and simulation to validate device performance.
• Configured interdigital transducer (IDT) signals (frequency, voltage) to adjust microparticle velocity.

Main Results:

• Successfully demonstrated automated, high-throughput microparticle manipulation in round and square maze chambers.
• Achieved rapid adjustment of microparticle motion velocity (within 0.1 s).
• Validated the device's feasibility for targeted microparticle transportation in complex environments.

Conclusions:

• The TSAW device offers a low-cost, compact, and contactless solution for microparticle trajectory manipulation.
• Potential applications include cell-directed transportation, chemical mixing, and drug delivery.
• This technology advances automated handling of microparticles in intricate microfluidic systems.