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Uveitis in Behçet disease - an update.
1Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University.
Current Opinion in Rheumatology
|October 18, 2022
Summary
Behçet disease (BD) uveitis, a major cause of morbidity, is better understood with new criteria and algorithms. Advanced therapies like interferon-α, infliximab, and adalimumab show superior efficacy for managing this ocular condition.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Uveitis is a significant manifestation of Behçet disease (BD), often leading to high morbidity.
- Recent data review focuses on advancements in understanding and managing BD uveitis.
Approach:
- Review of recently published data on Behçet disease uveitis.
- Analysis of classification criteria, diagnostic algorithms, and treatment outcomes.
Key Points:
- Male predominance and posterior segment inflammation are common in BD uveitis.
- Poor visual outcomes are predicted by high uveitis severity, posterior pole leakage on fluorescein angiography, and outer retinal disruption on OCT.
- OCT-angiography may reveal subclinical retinal capillary changes.
Conclusions:
- New classification criteria and diagnostic algorithms aid in patient selection and prediction of BD uveitis.
- Fluorescein angiography and OCT are standard imaging tools; OCT-angiography's clinical relevance is under investigation.
- Interferon-α, infliximab, and adalimumab demonstrate superior efficacy over conventional therapies for BD uveitis.
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