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Updated: Aug 25, 2025

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Improved Syntheses of 4'-Vinylbenzo-3n-Crown-n Ethers (n = 5-7)
Liulei Ma1, Jesus Daniel Loya1, Michael Findlater2
1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Abstract:
A convenient, high-yielding, and scalable synthetic approach to the construction of 4'-vinylbenzocrown ethers has been developed, which employs a decarboxylation and cyclization strategy. Using this method, a wide-ranging class of vinylbenzocrown ethers can be efficiently obtained. The identity of the crown ethers was further established using single-crystal X-ray diffraction studies. Two of the vinylbenzocrown ethers crystallize with water, affording infinite supramolecular assemblies containing hydrogen-bonded water molecules.
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