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Skeletal interoception in bone homeostasis and pain
1Center for Musculoskeletal Research, Department of Orthopaedic Surgery and Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA.
Cell Metabolism
|October 18, 2022
Summary
Interoception, the body's sense of its internal state, is crucial for metabolic homeostasis and bone health. New research highlights how skeletal interoception influences bone and overall metabolism, offering therapeutic potential.
Area of Science:
- Physiology
- Metabolism
- Neuroscience
Background:
- Interoception regulates physiological status and metabolic homeostasis through feeding, glucose, and lipid metabolism.
- Skeletal remodeling is energy-intensive and contributes to metabolic balance.
- Recent findings reveal the nervous system's role in regulating skeletal metabolism and bone homeostasis via skeletal interoception.
Purpose of the Study:
- To discuss the general effects of interoception on the skeleton and whole-body metabolism.
- To explore the role of skeletal interoception in regulating bone homeostasis.
- To examine pathological conditions, skeletal pain, and future therapeutic strategies related to skeletal interoception.
Main Methods:
- Literature review and synthesis of current evidence on interoception and skeletal metabolism.
- Discussion of neuro-skeletal interactions.
- Exploration of clinical implications and future research directions.
Main Results:
- Interoception is a key regulator of metabolic homeostasis.
- The skeleton is intricately linked to nervous system regulation and interoception.
- Skeletal interoception plays a significant role in maintaining bone homeostasis and overall metabolic balance.
Conclusions:
- Skeletal interoception is a critical factor in maintaining bone and whole-body metabolic health.
- Understanding these neuro-skeletal interactions opens avenues for novel therapeutic interventions.
- Further research is needed to fully elucidate the mechanisms and harness the therapeutic potential of skeletal interoception.
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