Related Experiment Video
Updated: Aug 25, 2025

Author Spotlight: An Efficient and Robust Software for Automated Fusion of Multiple Preclinical Imaging Modalities
Published on: October 27, 2023
Performance enhancement of coherent modulation imaging in the presence of missing data
Abstract:
Coherent diffraction imaging (CDI) has become a powerful imaging modality in synchrotron x-ray imaging and electron microscopy communities. In the far-field geometry, image quality of CDI depends strongly on the performance of detector; specifically, the dynamic range, pixel size, and the absence of missing data. Coherent modulation imaging (CMI), an innovative variant of CDI, improves the algorithmic convergence by inserting a modulator upstream of the detector. Here, we explore the potential of CMI in eliminating nonideal effects of detector by modifying the modulus constraint to extrapolate the missing part of diffraction pattern. Nine folds of extrapolation in area of diffraction pattern have been shown feasible in experiment; while sixteen folds in simulation. For image quality measured by Structural Similarity (SSIM), our method shows a maximum of 32% improvement over the traditional method. Our method provides a way to alleviate the effects of beamstop, gaps between modules, limited dynamic range, and limited detector size for CMI.
Related Concept Videos
Reconstruction of Signal using Interpolation
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Linear Approximation in Frequency Domain
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....
Propagation of Uncertainty from Systematic Error
Aliasing
If the sampling frequency is below the Nyquist rate, these replicas overlap, preventing the original...
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...

