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Metastatic skull base chordoma: A systematic review
Kurtis Young1, Torbjoern Nielsen1, Hannah Bulosan1
1University of Hawai'i at Mānoa John A. Burns School of Medicine Honolulu Hawaii USA.
Laryngoscope Investigative Otolaryngology
|October 19, 2022
Summary
Metastatic skull base chordomas most commonly spread to the lungs and bone. The median overall survival for these patients was 84 months, regardless of surgical approach or metastasis site.
Area of Science:
- Oncology
- Neurosurgery
- Pathology
Background:
- Skull base chordomas are rare bone tumors.
- Metastatic spread significantly impacts prognosis.
- Understanding metastatic patterns is crucial for treatment.
Purpose of the Study:
- To review clinical features of metastatic skull base chordomas.
- To analyze management strategies and patient outcomes.
- To identify common sites of metastasis.
Main Methods:
- Systematic review of literature.
- Searched PubMed, Web of Science, and EBSCOhost.
- Data extracted from 38 studies including 40 cases.
Main Results:
- Average age at presentation was 28.5 years.
- Metastases commonly occurred in the lungs (32.5%) and bone.
- Median overall survival was 84 months.
Conclusions:
- Lungs and bone are primary sites for skull base chordoma metastasis.
- Overall survival did not significantly differ based on surgery extent or metastasis site.
