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Causality of Opportunistic Pathogen Klebsiella pneumoniae to Hypertension Development

Jing Li1,2, Qiannan Gao1, Yiyangzi Ma3

  • 1Hypertension Center, FuWai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Xicheng District, Beijing, China (J.L., Q.G., Y.D., S.L., J.C.).

Hypertension (Dallas, Tex. : 1979)
|October 19, 2022
PubMed
Abstract

Insights

The opportunistic pathogen Klebsiella pneumoniae directly contributes to hypertension by elevating blood pressure. This bacterium causes intestinal damage, metabolic changes, and kidney dysfunction, highlighting its role in hypertension pathogenesis.

Area of Science:

  • Microbiology
  • Cardiovascular Science
  • Gastroenterology

Background:

  • Strong association between gut microbiome and hypertension noted.
  • Specific bacterial species contributing to hypertension remain unidentified.
  • This study investigates Klebsiella pneumoniae as a potential causal factor in hypertension.

Approach:

  • Validated Klebsiella pneumoniae enrichment in hypertensive patients via meta-analysis.
  • Inoculated Klebsiella pneumoniae into germ-free, antibiotic-pretreated, and conventional mice.
  • Examined effects on blood pressure, cardiac function, and organ pathology.

Key Points:

  • Klebsiella pneumoniae administration increased blood pressure and cardiac hypertrophy in mice.
  • The bacterium induced intestinal damage, tight junction protein deficiency, and metabolic alterations (e.g., stearoylethanolamide depletion).
  • Renal transcriptome analysis revealed significant upregulation of hypertension-related genes.

Conclusions:

  • Klebsiella pneumoniae enrichment is a direct contributor to elevated blood pressure and hypertension.
  • Intestinal damage, fecal metabolic changes, and renal transcriptome shifts mediated by Klebsiella pneumoniae are key factors in hypertension pathogenesis.
Keywords:
Klebsiella pneumoniaeblood pressurehypertensionintestinesmicrobiota

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