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Secondary cutaneous diffuse large B-cell lymphoma presenting with focal vesicular lesions
Sarah F Alsukait1, Leena Y Taher, Mohammed I AlJasser
1Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. salsukait@gmail.com.
Dermatology Online Journal
|October 19, 2022
Summary
Blistering skin lesions are a rare sign of B-cell lymphoma. This case study details a patient with diffuse large B-cell lymphoma presenting with vesicular nodules indicating secondary cutaneous spread.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- B-cell lymphoma, a malignancy of lymphocytes, can manifest with diverse clinical presentations.
- Cutaneous involvement in lymphoma is recognized but typically presents as nodules or plaques, not blisters.
Observation:
- A patient with refractory systemic diffuse large B-cell lymphoma (DLBCL) developed skin lesions.
- The lesions appeared as nodules with overlying vesicular (blister-like) areas.
Findings:
- The observed vesicular nodules were histopathologically consistent with secondary cutaneous spread of DLBCL.
- This presentation is exceptionally rare, with only one prior case reported in medical literature.
Implications:
- Highlights the importance of considering cutaneous lymphoma in patients with unexplained blistering lesions, even with known systemic disease.
- Suggests that secondary cutaneous spread of DLBCL can present with unusual vesicular morphology.
- Underscores the need for thorough dermatological evaluation in lymphoma patients with new skin findings.
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