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Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
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Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

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The Association between the Fibrosis-4 Index and COVID-19: A Systematic Review and Meta-Analysis

Guangyu Ao1, Anthony Li2, Jing Li1

  • 1Department of Nephrology, Chengdu First People's Hospital, Chengdu, Sichuan, China.

Annals of Clinical and Laboratory Science
|October 19, 2022
PubMed

Insights

A high Fibrosis-4 (FIB-4) score indicates a greater risk of severe outcomes in COVID-19 patients. This meta-analysis confirms FIB-4 as a predictor of mortality and disease progression in COVID-19.

Area of Science:

  • * Hepatology and Infectious Diseases
  • * Clinical Prognostics and Biomarkers

Background:

  • * The prognostic value of the Fibrosis-4 (FIB-4) score in COVID-19 patients remains debated.
  • * Accurate prediction of COVID-19 severity and mortality is crucial for patient management.

Approach:

  • * Systematic review and meta-analysis of thirteen studies.
  • * Inclusion of data from PubMed, Embase, and Cochrane databases.
  • * Utilized fixed- or random-effects models to assess heterogeneity.

Key Points:

  • * Higher FIB-4 index significantly correlated with increased odds of mortality (OR=5.1) and ICU admission (OR=2.32) in unadjusted analyses.
  • * Adjusted analyses revealed higher FIB-4 index associated with increased risk of mortality (OR=3.01) and mechanical ventilation (OR=3.76).
  • * Elevated FIB-4 scores consistently predicted worse outcomes across multiple studies.

Conclusions:

  • * The Fibrosis-4 index is a valuable prognostic marker for COVID-19.
  • * High FIB-4 scores are strongly associated with increased severity and mortality in COVID-19 patients.
  • * FIB-4 can aid in identifying high-risk individuals requiring closer monitoring and intervention.
Abstract

Keywords:
COVID-19fibrosis-4 indexmeta-analysismortalitysevere

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