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Primary Effusion Lymphoma-like ATL Developing during Hemodialysis

Miharu Masaki1, Yuki Okushi2, Atsushi Saito2

  • 1Department of Cardiology, Kanazawa Medical University, Japan.

Internal Medicine (Tokyo, Japan)
|October 19, 2022
PubMed

We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of lactate dehydrogenase (LDH), calcium and soluble interleukin-2 receptor (sIL-2R) along with antibodies to human T-cell leukemia virus type 1 (HTLV-1) were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of brentuximab vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.

Keywords:
ATLchronic renal failureprimary effusion lymphoma

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