Related Experiment Video
Updated: Aug 24, 2025
12:58
Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
9.4K
Primary Effusion Lymphoma-like ATL Developing during Hemodialysis.
Miharu Masaki1, Yuki Okushi2, Atsushi Saito2
1Department of Cardiology, Kanazawa Medical University, Japan.
Internal Medicine (Tokyo, Japan)
|October 19, 2022
Summary
This study details a rare case of primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) in a patient undergoing hemodialysis. Treatment with brentuximab vedotin showed a positive response, highlighting the need for new targeted therapies.
Area of Science:
- Hematology
- Oncology
- Virology
Background:
- Adult T-cell leukemia/lymphoma (ATL) is a lymphoproliferative malignancy associated with human T-cell leukemia virus type 1 (HTLV-1).
- Primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma, typically seen in advanced HIV infection.
Observation:
- A 77-year-old male on hemodialysis presented with fever and ascites.
- Laboratory findings included elevated lactate dehydrogenase (LDH), calcium, soluble interleukin-2 receptor (sIL-2R), and positive HTLV-1 antibodies.
- Ascitic fluid contained lymphoma cells positive for HTLV-1 proviral DNA, with no neoplastic cells detected in peripheral blood or bone marrow, and no lymphadenopathy.
Findings:
- The patient was diagnosed with acute-type primary effusion lymphoma-like ATL (PEL-like ATL).
- Administration of brentuximab vedotin led to a decrease in serum LDH, sIL-2R, and atypical cells in ascites.
- This case demonstrates a unique presentation of PEL-like ATL in the context of chronic kidney disease and hemodialysis.
Implications:
- This case highlights the importance of considering rare ATL subtypes in patients with unexplained effusions, particularly those on hemodialysis.
- Brentuximab vedotin shows potential efficacy in managing PEL-like ATL.
- Further research into novel molecular-targeted therapies is crucial for improving outcomes in patients with PEL-like ATL.
Related Concept Videos
01:24Hemodialysis II: Procedure and Complications
101
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
101
01:25Hemodialysis I: Introduction
216
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
216
01:25Hemodialysis III: Nursing Management
135
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
135
01:27Dialysis
438
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
438
01:24Nephrotic Syndrome I : Introduction
18
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
18
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
87
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
87