Related Experiment Video

Updated: Aug 24, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Case report: What course to follow when left bundle branch pacing encounters acute myocardial infarction?

Xiaojiang Zhang1, Yanzhuo Ma1, Leisheng Ru1

  • 1980th Hospital of the Joint Logistic Support Force of PLA, Shijiazhuang, China.

Frontiers in Cardiovascular Medicine
|October 20, 2022
PubMed

Insights

Left bundle branch pacing (LBBP) offers a more physiologic alternative to traditional pacing. A rare case showed transient pacing loss during myocardial infarction, highlighting LBBP

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Pacing

Background:

  • His-bundle pacing (HBP) offers physiologic pacing but has limitations like higher thresholds.
  • Left bundle branch pacing (LBBP) presents an alternative with potentially lower thresholds and improved cardiac function.

Observation:

  • A rare case of transient loss of ventricular capture occurred in a patient with acute anterior wall myocardial infarction undergoing LBBP.
  • Pacemaker function partially recovered as myocardial ischemia improved.

Findings:

  • LBBP may be susceptible to capture loss during acute ischemic events.
  • Myocardial infarction can transiently impair LBBP efficacy.

Implications:

  • Understanding LBBP's response to ischemia is crucial for patient management.
  • Further research is needed on LBBP adaptations, advantages, limitations, and long-term safety.

Keywords:
AV blockacute myocardial infarction (AMI)left bundle branch pacing (LBBP)pacemaker dysfunctionthe pacing threshold

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