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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors
Hajaralsadat Hosseini-Dastgerdi1, Fatemeh Kharazmi1, Ali-Asghar Pourshanazari1
1Water & Electrolytes Research Center and Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
International Journal of Nephrology
|October 20, 2022
Summary
Renal sympathetic and renin-angiotensin systems interact, influencing kidney function. Renal denervation may normalize changes in angiotensin II receptors, improving kidney disease.
Area of Science:
- Nephrology
- Cardiovascular Physiology
- Endocrinology
Background:
- The sympathetic nervous system and renin-angiotensin system (RAS) are key regulators of renal hemodynamics and function.
- These systems interact, with angiotensin II (Ang II) affecting norepinephrine secretion and sympathetic activity influencing RAS receptor expression.
Purpose of the Study:
- To investigate the interplay between renal sympathetic activity and Angiotensin II (Ang II) receptors.
- To explore the therapeutic potential of modulating these interactions in kidney disease.
Main Methods:
- Review of existing literature on sympathetic-RAS interactions in the kidney.
- Analysis of pathological conditions involving increased renal sympathetic tone.
- Examination of the effects of renal denervation on Ang II receptor expression and distribution.
Main Results:
- Increased renal sympathetic tone alters the expression and distribution of renal Ang II receptors.
- Renal denervation can normalize these receptor changes in pathological states.
- Modulation of renal sympathetics impacts Ang II receptor function and kidney function.
Conclusions:
- The sympathetic nervous system significantly influences the renin-angiotensin system within the kidney.
- Targeting renal sympathetic activity, potentially through renal denervation, offers a strategy to improve kidney function by normalizing Ang II receptor expression.
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