Sex Difference in MasR Expression and Functions in the Renal System
Samira Choopani1, Mehdi Nematbakhsh2
1Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal of the Renin-Angiotensin-Aldosterone System : JRAAS
|September 23, 2022
Summary
Sex differences significantly impact the Mas receptor (MasR) in the kidney. This review explores how MasR expression and function vary between sexes in both healthy and diseased states.
Area of Science:
- Physiology
- Endocrinology
- Nephrology
Background:
- The renin-angiotensin system (RAS) regulates body fluid and hemostasis.
- Key components include angiotensin 1-7 (Ang 1-7), Mas receptor (MasR), and Angiotensin II (Ang II) acting via AT1R and AT2R.
- MasR and AT2R share vasodilatory functions, while AT1R is vasoconstrictive.
Purpose of the Study:
- To review the role of sex differences in MasR expression and function within the renal system.
- To examine these roles under both physiological and pathological conditions.
Main Methods:
- Literature review focusing on MasR, Ang 1-7, and sex differences in the renal system.
- Analysis of interactions between MasR, Ang II receptors, and other factors like sex hormones.
- Consideration of pathological conditions affecting MasR.
Main Results:
- MasR influences numerous organs and acts as a paracrine hormone.
- Ang 1-7's renal effects are complex, influenced by hydration, sympathetic activity, and RAS status.
- MasR expression and function are more intricate than Ang II receptors and are modulated by sex hormones and disease states.
Conclusions:
- Sex differences play a crucial role in MasR expression and function in the kidney.
- MasR interacts with other RAS components and is altered by hypertension, diabetes, and ischemia-reperfusion.
- Further research is needed to fully elucidate the sex-specific roles of MasR in renal physiology and pathology.
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