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Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview

Pads Palihaderu1, Bilm Mendis1, Jmkjk Premarathne2

  • 1Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya, Sri Lanka.

Epigenetics Insights
|October 20, 2022
PubMed

Insights

MicroRNAs (miRNAs) show promise for treating Type 2 diabetes mellitus by regulating glucose and lipid metabolism. While research is ongoing, few miRNA therapies have reached clinical trials, highlighting the need for further investigation.

Area of Science:

  • Biochemistry
  • Genetics
  • Endocrinology

Background:

  • MicroRNAs (miRNAs) are stable molecules with therapeutic potential, including horizontal transmission.
  • MiRNAs are implicated in the pathogenesis of Type 2 diabetes mellitus (T2DM).
  • Current miRNA-based T2DM therapies are in early developmental stages.

Purpose of the Study:

  • To review recent advancements in miRNA-based therapeutics for T2DM.
  • To discuss the implications, challenges, and future directions for miRNA therapies in T2DM treatment.

Main Methods:

  • Review of recent scientific literature on miRNA therapeutics for T2DM.
  • Analysis of in-vivo and cell culture studies on miRNA administration.
  • Evaluation of current clinical trial status for miRNA-based T2DM treatments.

Main Results:

  • In-vivo administration of miRNA mimics/antimiRs has positively modulated glucose and lipid metabolism.
  • Cell culture studies suggest miRNAs may promote beta cell regeneration.
  • Limited miRNA-based therapeutic approaches for T2DM have progressed to clinical phases.

Conclusions:

  • MiRNAs hold significant therapeutic potential for T2DM due to their role in disease pathogenesis and metabolic regulation.
  • Further research and clinical development are crucial to realize the potential of miRNA therapeutics for T2DM.
  • Addressing current gaps is essential for advancing miRNA-based treatments for Type 2 diabetes mellitus.
Keywords:
antimiRsbeta-cell differentiationmetabolismmiRNAmiRNA-mimicstherapeutic

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