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Updated: Aug 24, 2025

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BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.

Huong Nguyen1,2, Godwin Sokpor1,3,4, Arpan Parichha5

  • 1Institute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany.

Frontiers in Cell and Developmental Biology
|October 20, 2022
PubMed
Summary
This summary is machine-generated.

The BAF chromatin remodeling complex is crucial for proper mouse forebrain development. Its absence disrupts cortical patterning and cell distribution by affecting the cortical hem and LHX2 interactions.

Keywords:
BAF (mSWI/SNF) complexLhx2cortical developmentcortical hemdorsal telencephalonhippocampuspatterning

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Area of Science:

  • Developmental Neuroscience
  • Chromatin Biology
  • Molecular Genetics

Background:

  • Early forebrain patterning is essential for establishing brain structure and function.
  • While signaling and transcription factors are known regulators, the role of chromatin structure in cortical patterning remains unclear.

Purpose of the Study:

  • To investigate the role of the BAF chromatin remodeling complex in the spatiotemporal patterning of the mouse dorsal telencephalon.
  • To elucidate the molecular mechanisms by which the BAF complex influences cortical development.

Main Methods:

  • Conditional deletion of BAF complex subunits (BAF155, BAF170) in the mouse dorsal telencephalic neuroepithelium.
  • Analysis of morphological and cellular changes using immunohistochemistry and in situ hybridization.
  • Molecular investigation using RNA sequencing, Co-immunoprecipitation, and mass spectrometry.

Main Results:

  • Ablation of the BAF complex led to the expansion of the cortical hem and medial cortex, disrupting normal boundaries.
  • Loss of BAF complex function resulted in failed hippocampal primordium specification, compromised mediolateral cortical patterning, and disturbed cortical identity.
  • The BAF complex interacts with LHX2, suppressing cortical hem fate and driving an LHX2-dependent transcriptional program for dorsal telencephalon patterning.

Conclusions:

  • The BAF chromatin remodeling complex plays a critical role in regulating dorsal telencephalon patterning during mouse brain development.
  • BAF complex acts by suppressing cortical hem fate and interacting with LHX2 to control essential transcriptional programs.
  • A synergistic mechanism between the BAF complex and LHX2 is proposed for regulating forebrain patterning and ontogeny.