Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Antigen Processing Pathways01:31

Antigen Processing Pathways

1.2K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.2K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

626
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
626
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

338
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
338
Development of Immunocompetence01:22

Development of Immunocompetence

419
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
419
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

881
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
881

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unexpected genetically determined immune dysregulation with liver involvement: GIMAP5 therapeutic dilemmas between targeted therapy and HSCT.

Frontiers in immunology·2026
Same author

ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype.

Journal of human immunity·2026
Same author

LRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses.

EMBO reports·2026
Same author

Reply to: Comment on: Investigating Biomarkers for Inborn Errors of Immunity in a Prospective Study of Patients With Autoimmune Cytopenia.

Pediatric blood & cancer·2026
Same author

How I Treat: STAT3 hyper IgE syndrome.

Journal of human immunity·2026
Same author

The Landscape of Genetically Driven Immune Disorders.

NEJM evidence·2026
Same journal

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease.

Annual review of pathology·2026
Same journal

Integration and Intersection of Cancer Metabolism with Epigenetic Pathways in Gliomas.

Annual review of pathology·2025
Same journal

The Role of Fibroblasts Across Inflammation and Immunity.

Annual review of pathology·2025
Same journal

The Role of MicroRNAs in Viral and Bacterial Infections.

Annual review of pathology·2025
Same journal

Role of Immune Cells in Hepatitis B Virus and Associated Sequelae.

Annual review of pathology·2025
Same journal

Pathology of the Coronary Arteries and Myocardium in Kawasaki Disease.

Annual review of pathology·2025
See all related articles

Related Experiment Video

Updated: Aug 24, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.4K

Common Variable Immunodeficiency: More Pathways than Roads to Rome.

Xiao P Peng1,2, Andrés Caballero-Oteyza1,3, Bodo Grimbacher1,3,4,5,6

  • 1Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany;

Annual Review of Pathology
|October 20, 2022
PubMed
Summary
This summary is machine-generated.

Common Variable Immunodeficiency (CVID) has evolved significantly over 50 years. Research now explores genetic, epigenetic, and somatic factors, revealing diverse mechanisms and informing broader immunity understanding.

Keywords:
B cell developmentgeneticsimmunodeficiencyinborn errors of immunitymutationpathophysiologyprimary antibody deficiencyvariant

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.9K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.8K

Related Experiment Videos

Last Updated: Aug 24, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.4K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.9K
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
14:14

Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR

Published on: December 6, 2014

16.8K

Area of Science:

  • Immunology
  • Genetics
  • Clinical Medicine

Background:

  • Common Variable Immunodeficiency (CVID) was introduced 50 years ago for antibody deficiencies.
  • Despite revisions, CVID definition and classification remain debated.
  • The field of inborn errors of immunity (IEIs) has expanded significantly.

Purpose of the Study:

  • To review the evolution of CVID understanding and its impact on diagnosis and management.
  • To highlight the increasing recognition of genetic and other factors contributing to CVID.
  • To discuss the implications of CVID research for understanding broader immune system function.

Main Methods:

  • Review of historical literature and recent research on CVID.
  • Analysis of diagnostic and classification criteria evolution.
  • Examination of genetic, polygenic, epigenetic, and somatic contributions to CVID.

Main Results:

  • CVID encompasses a growing number of monogenic disorders.
  • Significant genotypic and phenotypic overlap exists between CVID and other immunological conditions.
  • Routine genotyping reveals diverse pathophysiological mechanisms in CVID.

Conclusions:

  • CVID research has profoundly advanced the understanding of adaptive and innate immunity.
  • Continued investigation into CVID pathogenesis is crucial for refining diagnosis and treatment.
  • The complexity of CVID underscores the intricate nature of the human immune system.