Related Experiment Video

Updated: Aug 24, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Functional impact of androgen-targeted therapy on patients with castration-resistant prostate cancer

Tomasz M Beer1, Neal Shore2, Alicia Morgans3

  • 1Oregon Health and Science University Knight Cancer Institute Portland Oregon USA.

BJUI Compass
|October 21, 2022
PubMed
Abstract

Insights

Second-generation androgen receptor inhibitors improve prostate cancer survival but can affect physical and cognitive function. Careful selection of these drugs may help manage these side effects, improving patient quality of life.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Second-generation androgen receptor inhibitors (ARIs) enhance survival in prostate cancer patients undergoing androgen deprivation therapy.
  • However, ARIs can negatively impact physical and cognitive function, potentially reducing quality of life.

Purpose of the Study:

  • To review evidence on the effects of ARIs on physical and cognitive function in prostate cancer.
  • To explore how adverse effects influence treatment decisions for castration-resistant prostate cancer (CRPC).

Main Methods:

  • A literature search of MEDLINE (January 1998-June 2020) was conducted.
  • Keywords included prostate cancer, androgen deprivation, and physical/cognitive function.
  • 61 publications were analyzed.

Main Results:

  • ARIs can cause physical and cognitive decline, impacting patient independence and well-being.
  • Patient-reported outcomes show varied effects among ARIs, linked to their adverse event profiles.
  • Cognitive effects are assessed with validated instruments, but physical function impact analysis is limited.

Conclusions:

  • Managing physical or cognitive dysfunction risk is possible through appropriate ARI selection.
  • Standardization of assessment tools for physical and cognitive function is needed.
  • Future studies using validated tools will guide ARI treatment decisions in CRPC.
Keywords:
androgen deprivation therapyandrogen‐targeted therapycastration‐resistant prostate cancercognitive functionphysical function

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