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Updated: Jul 14, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Targeted Radionuclide Therapy: Current Landscape and Combination Approaches to Improve Oncology Outcomes
Julie Nonnekens1, Lauren A Byers2, Aman Chauhan3
1Erasmus MC Rotterdam Netherlands.
Summary
Targeted radionuclide therapy (TRT) shows promise for cancer treatment but often requires combination strategies. This review explores combining TRT with other therapies to improve patient outcomes and overcome resistance.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiopharmaceutical Therapy
Background:
- Targeted radionuclide therapy (TRT) delivers internal radiation to tumors.
- Approved TRT agents show promise for prostate cancer and neuroendocrine tumors.
- Patient relapse after TRT monotherapy necessitates improved treatment strategies.
Purpose of the Study:
- To review TRT properties and rationale for combination therapies.
- To discuss preclinical and clinical data on TRT combinations.
- To highlight future directions in TRT combination strategies.
Main Methods:
- Overview of beta- and alpha-emitting radionuclides.
- Review of combination regimens with hormone therapy, chemotherapy, immunotherapy, and others.
- Discussion of preclinical rationale, clinical data, and ongoing trials.
Main Results:
- TRT combination strategies aim to enhance efficacy and overcome resistance.
- Promising preclinical data supports early-phase clinical trials.
- Various TRT combination trials are underway, exploring different therapeutic pairings.
Conclusions:
- Combination TRT holds potential to improve patient outcomes in oncology.
- Further research into novel radionuclides and biomarkers is crucial.
- Optimizing TRT combination therapy requires a multi-faceted approach.
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