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Effect of isometric handgrip exercise on cognitive function: Current evidence, methodology, and safety considerations
Yuxin Zhu1,2, Shan He1, Fabian Herold3
1School of Physical Education, Guangzhou Sport University, Guangzhou, China.
Frontiers in Physiology
|October 21, 2022
Summary
Isometric handgrip exercise (IHE) shows a potential chronic benefit for cognitive function in adults. More research is needed to confirm these findings and explore clinical relevance for improving brain health.
Area of Science:
- Exercise Science
- Neuroscience
- Gerontology
Background:
- Cognitive function is vital for daily living and quality of life.
- Isometric handgrip exercise (IHE) is a promising intervention for health outcomes.
- Systematic review to assess IHE's impact on adult cognitive function.
Approach:
- Searched five databases (CINAHL, MEDLINE, SPORTDiscus, PsychINFO, Web of Science).
- Included 8 studies (4 acute varied intensity, 2 acute exhaustion, 2 chronic).
- Assessed methodological quality using the PEDro scale (mean score 6.75).
Key Points:
- Evidence for acute cognitive benefits from IHE is inconclusive.
- A trend suggests chronic IHE may positively impact cognitive function.
- Results require cautious interpretation due to limited evidence.
Conclusions:
- IHE's chronic effects on cognitive function warrant further investigation.
- The clinical relevance of IHE for cognitive enhancement needs more research.
- Methodology and safety considerations for IHE interventions require discussion.

