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Updated: Aug 24, 2025

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The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells

Ida Steiro1, Esten N Vandsemb1, Samah Elsaadi1

  • 1Center for Myeloma Research, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Oncotarget
|October 21, 2022
PubMed
Abstract

Insights

Matriptase, an enzyme, acts as a tumor suppressor in multiple myeloma (MM) by reducing cancer cell proliferation and migration. This finding suggests a new therapeutic target for this incurable plasma cell malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Hematology

Background:

  • Multiple myeloma (MM) is a fatal plasma cell cancer.
  • Matriptase, a serine protease, is implicated in carcinoma progression.
  • The role of matriptase in blood cancers like MM remains unclear.

Purpose of the Study:

  • To investigate the role and clinical relevance of matriptase in multiple myeloma.
  • To analyze matriptase expression in MM patient samples and cell lines.
  • To determine matriptase's effect on myeloma cell behavior.

Main Methods:

  • Studied mRNA expression of matriptase and its inhibitors (HAI-1, HAI-2) in MM cells.
  • Assessed matriptase's impact on myeloma cell migration and proliferation in vitro.
  • Utilized the CoMMpass database to evaluate clinical relevance in MM patients.

Main Results:

  • Matriptase was expressed in 96% of MM patient samples and all cell lines.
  • Matriptase overexpression reduced myeloma cell proliferation and migration.
  • Matriptase knockdown increased myeloma cell migration, and inhibited Src kinase activation.

Conclusions:

  • Matriptase may function as a tumor suppressor in multiple myeloma.
  • These findings suggest matriptase as a potential therapeutic target for MM.
Keywords:
Srcmatriptasemigrationmultiple myelomatumor suppressor

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