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Photoswitchable Microgels for Dynamic Macrophage Modulation.

Yuri Kim1, Ramar Thangam1,2, Jounghyun Yoo3

  • 1Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)
|October 21, 2022
PubMed

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Summary
This summary is machine-generated.

Researchers developed novel microgels that can be reversibly controlled by light. These smart materials can promote tissue regeneration or reduce inflammation by releasing proteins and altering cell interactions.

Area of Science:

  • Supramolecular chemistry
  • Biomaterials science
  • Nanotechnology

Background:

  • Dynamic manipulation of self-assembled structures is challenging under physiological conditions.
  • Existing methods often lead to irreversible changes or require harsh environments.
  • This limits their application in sensitive fields like biomedicine and environmental science.

Purpose of the Study:

  • To develop light-responsive microgels for dynamic control of supramolecular structures.
  • To investigate the use of near-infrared (NIR) and visible light for precise manipulation.
  • To explore applications in modulating host cell behavior for regenerative medicine.

Main Methods:

  • Synthesized azobenzene-derivative microgels stabilized by RGD-bearing polymers.
Keywords:
dynamic hydrogelsmacrophage adhesionmacrophage polarizationmicrogel swellingphotoswitchable microgels

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  • Utilized upconversion nanoparticles for NIR-light-triggered swelling (cis-azobenzene formation).
  • Employed visible light for deswelling (trans-azobenzene formation) via molecular dynamics simulations and real-time imaging.

    • Main Results:

    • NIR light induced microgel swelling, increasing Arg-Gly-Asp (RGD) availability and interleukin-4 release.
    • Visible light induced microgel deswelling, reducing RGD availability and suppressing macrophage adhesion.
    • NIR-induced swelling promoted pro-regenerative macrophage polarization, while visible light induced pro-inflammatory polarization.

    Conclusions:

    • Developed stable, non-toxic, photoswitchable microgels with tunable RGD availability.
    • Demonstrated light-controlled modulation of macrophage behavior for regenerative applications.
    • Highlighted the potential for versatile ligand presentation and protein delivery in cytocompatible materials.