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Proton pump inhibitors-induced psychiatric symptoms
1Department of Gastroenterology, Hangzhou Red Cross Hospital/Integrated Traditional Chinese and Western Medicine Hospital of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.
Neurocase
|October 21, 2022
Summary
Proton pump inhibitors (PPIs) can rarely cause psychiatric symptoms like motor hallucinations. Discontinuing PPIs and/or antipsychotics typically leads to recovery with a good prognosis.
Area of Science:
- Pharmacology
- Neuroscience
- Gastroenterology
Background:
- Proton pump inhibitors (PPIs) are common treatments for gastrointestinal disorders.
- Drug-induced psychiatric symptoms from PPIs are rare but warrant investigation.
- Understanding these adverse effects is crucial for patient management.
Purpose of the Study:
- To investigate the clinical presentations of PPI-induced psychiatric symptoms.
- To explore diagnostic approaches and treatment strategies.
- To evaluate the prognosis of patients experiencing these adverse effects.
Main Methods:
- Case report of a patient experiencing PPI-induced motor hallucination.
- Utilized Delirium Rating Scale and Hamilton Anxiety Scale for assessment.
- Documented outcomes following drug withdrawal and treatment.
Main Results:
- The case presented with motor hallucination, transient delirium, and anxiety.
- Symptoms resolved after discontinuing proton pump inhibitors.
- No standard treatment protocol exists; strategies include drug withdrawal and/or antipsychotics.
Conclusions:
- PPI-induced psychiatric symptoms are generally benign.
- Early diagnosis and intervention, such as discontinuing PPIs, improve patient prognosis.
- Recurrence of symptoms appears to be rare.
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