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Evaluation and Treatment of Psychogenic Nonepileptic Seizures

Nicholas J Beimer1, William Curt LaFrance2

  • 1Department of Neurology, Michigan Medicine, University of Michigan, F2593 UH South, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5223, USA; Department of Psychiatry, Michigan Medicine, University of Michigan, F2593 UH South, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5223, USA.

Neurologic Clinics
|October 21, 2022
PubMed

Keywords:
BehavioralFunctionalMultidisciplinaryNonepilepticPsychogenicSeizuresTherapyTreatment

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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