Related Experiment Video
Updated: Aug 24, 2025
Determining Bile Duct Density in the Mouse Liver
Published on: April 30, 2019
Primary Biliary Cholangitis in Males: Pathogenesis, Clinical Presentation, and Prognosis
Mina Shaker1, Natalie Mansour1, Binu V John2
1Division of Hepatology, Miami VA Medical Center 1201 NW 16th Street, Miami, FL 33125 USA.
Abstract:
Primary biliary cholangitis (PBC) is an immune-mediated chronic liver disease characterized by progressive cholestasis, bile duct destruction, biliary fibrosis, and cirrhosis. Patients who respond to ursodeoxycholic acid have an expected survival similar to the general population. Although PBC primarily affects females, the prevalence in males is higher than was previously believed, with contemporary studies suggesting a female-to-male ratio of 4-6:1. A diagnosis of PBC is often delayed among males because of the myth that PBC is rare in males.
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