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HER3 in cancer: from the bench to the bedside

Lucía Gandullo-Sánchez1, Alberto Ocaña2, Atanasio Pandiella3

  • 1Instituto de Biología Molecular y Celular del Cáncer, CSIC, IBSAL and CIBERONC, Campus Miguel de Unamuno, 37007, Salamanca, Spain.

Journal of Experimental & Clinical Cancer Research : CR
|October 22, 2022
PubMed

Insights

Targeting the HER3 protein shows therapeutic potential in various cancers. Research explores antibodies, aptamers, and vaccines to overcome drug resistance and improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Development

Background:

  • The Human Epidermal growth factor Receptor 3 (HER3) protein, part of the ErbB/HER receptor tyrosine kinase (RTK) family, is frequently expressed in numerous tumor types.
  • HER3 plays a crucial role in promoting cancer cell proliferation and is implicated in resistance to therapies targeting other HER receptors (e.g., EGFR, HER2) and some chemotherapeutic agents.

Purpose of the Study:

  • To review the current landscape of preclinical and clinical development of therapeutic agents targeting HER3.
  • To highlight the significance of HER3 as a therapeutic target due to its role in cancer progression and drug resistance.

Main Methods:

  • Review of preclinical and clinical studies on HER3-targeting agents.
  • Categorization of therapeutic strategies, including antibodies, antibody derivatives, aptamers, vaccines, and siRNAs.

Main Results:

  • Development of two main classes of HER3-targeting agents: antibodies/derivatives and other modalities like aptamers and siRNAs.
  • Ongoing efforts in both preclinical and clinical settings to evaluate the efficacy of these HER3-targeting drugs.

Conclusions:

  • Targeting HER3 presents a promising therapeutic strategy for various cancers, particularly in overcoming resistance mechanisms.
  • Further development and clinical evaluation of HER3-directed therapies are essential to realize their full clinical potential.
Keywords:
Cancer therapyHER3Receptor tyrosine kinases

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