Related Experiment Video
Updated: Aug 24, 2025
06:22
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
722
Sudden Cardiac Death in Patients With Type 1 Versus Type 2 Diabetes
Faye L Norby1, Kyndaron Reinier1, Audrey Uy-Evanado1
1Center for Cardiac Arrest Prevention, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA.
Mayo Clinic Proceedings
|October 22, 2022
Summary
Type 1 diabetes (T1D) significantly increases sudden cardiac arrest (SCA) risk more than type 2 diabetes (T2D). T1D patients experienced worse outcomes after SCA, indicating a need for tailored prevention strategies.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Diabetes mellitus, encompassing type 1 (T1D) and type 2 (T2D), is a significant risk factor for cardiovascular diseases.
- Sudden cardiac arrest (SCA) remains a leading cause of mortality worldwide, with diabetes potentially influencing its incidence and outcomes.
Purpose of the Study:
- To investigate the differential association between T1D and T2D and the risk of SCA.
- To compare the outcomes following SCA in individuals with T1D versus T2D.
Main Methods:
- A prospective, community-based case-control study involving 2771 SCA cases and 8313 matched controls (age ≥18 years).
- Logistic regression analysis was employed to assess the independent association of diabetes, T1D, and T2D with SCA risk.
- Data were collected from February 2002 to November 2019.
Main Results:
- Diabetes was present in 36.7% of SCA cases and 23.8% of controls.
- T1D demonstrated a significantly higher odds ratio (4.36) for SCA compared to T2D (1.45) after multivariable adjustment.
- Individuals with T1D had 2.41 times higher odds of SCA compared to those with T2D, with poorer survival and resuscitation rates.
Conclusions:
- T1D is more strongly associated with SCA risk than T2D.
- Outcomes following SCA are less favorable in patients with T1D compared to T2D.
- Diabetes type should be considered in risk stratification and the development of preventive strategies for SCA.
More Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
01:22Diabetes Mellitus: Overview and Type I Subtype
2.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.9K
01:20Pathophysiology of Diabetes
1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
01:36Carbohydrate Metabolism
11.4K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.4K
01:15Diabetes: Symptoms, Diagnosis, and Complications
653
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
653
01:30Coronary Artery Disease III: Clinical Manifestations
25
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
25