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Monkeypox virus vaccine evolution and global preparedness for vaccination
Chiranjib Chakraborty1, Manojit Bhattacharya2, Ashish Ranjan Sharma3
1Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal 700126, India.
International Immunopharmacology
|October 24, 2022
Summary
Smallpox vaccines offer protection against monkeypox (MPX). This study reviews MPX vaccines, discusses smallpox vaccination models for MPX eradication, and examines global vaccination preparedness.
Area of Science:
- Epidemiology
- Vaccinology
- Public Health
Background:
- The global emergence of monkeypox (MPX) presents a significant public health threat, with increasing cases worldwide, particularly in non-African regions.
- Existing smallpox vaccines have demonstrated efficacy in protecting against MPX infection, highlighting a crucial intervention strategy.
Purpose of the Study:
- To review available smallpox vaccines for MPX prevention and vaccination strategies.
- To analyze smallpox vaccination eradication models for potential application to MPX.
- To assess global vaccination preparedness for MPX.
Main Methods:
- Literature review of research on MPX and smallpox vaccines.
- Statistical modeling using historical smallpox eradication data from Central and West Africa (1967-1972).
- Comparative analysis of vaccination preparedness in various countries (USA, UK, Canada, Denmark, Germany).
Main Results:
- Smallpox vaccines are effective against MPX.
- Smallpox eradication models show potential utility for MPX control in resource-limited settings.
- Vaccination preparedness varies across surveyed countries.
Conclusions:
- Smallpox vaccines are a viable tool for combating the MPX outbreak.
- Mathematical models derived from smallpox eradication efforts can inform MPX control strategies.
- International collaboration and preparedness are essential for effective MPX management.
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