Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Utility of an Ex Vivo Functional Test in Personalized Cancer Treatment.

Journal of personalized medicine·2026

Same author

Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes.

Cell reports. Medicine·2026

Same author

Biosynthetic gene clusters in <i>Pseudomonas viridiflava</i> have a fitness cost during <i>Arabidopsis thaliana</i> infection.

mSystems·2026

Same author

Serum-antibody Profiling of H3N2-infected Ferrets Using a Combinatorial Phage-display Random Peptide Library.

Journal of molecular biology·2026

Same author

Harnessing random peptide mixtures to combat multidrug-resistant fungal infections.

mBio·2026

Same author

Maternal antibodies regulate the establishment of murine oral and salivary mucosal immunity.

Nature communications·2026

Same journal

Mechanistic constraints in dengue severity: a systematic review with evidence stratification and agent-based evaluation of logical sufficiency.

Frontiers in immunology·2026

Same journal

Circadian control of immune homeostasis in cardiovascular health and disease.

Frontiers in immunology·2026

Same journal

An IHC-derived TLS-CD8-macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC.

Frontiers in immunology·2026

Same journal

AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.

Frontiers in immunology·2026

Same journal

Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming.

Frontiers in immunology·2026

Same journal

A self-perpetuating neuron-intrinsic GSDMD-mtDNA-AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury.

Frontiers in immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 24, 2025

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Targeted nanoparticles modify neutrophil function in vivo.

Sandra Völs¹, Naomi Kaisar-Iluz^2,3, Merav E Shaul^2,3

¹Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, Jerusalem, Israel.

Frontiers in Immunology

|October 24, 2022

Summary

This summary is machine-generated.

Researchers identified peptides that target neutrophils, enabling nanoparticle delivery for specific immune modulation. This breakthrough offers a novel immunotherapy approach for various diseases by manipulating neutrophil function.

Keywords:

inflammation nanoparticles neutrophil reactive oxygen species targeted delivery

More Related Videos

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Related Experiment Videos

Last Updated: Aug 24, 2025

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Area of Science:

Immunology
Nanotechnology
Therapeutics

Background:

Neutrophils are crucial immune cells involved in numerous diseases.
Manipulating neutrophil function presents a promising immunotherapeutic strategy.
Neutrophils' short lifespan and large numbers pose challenges for therapeutic targeting.

Purpose of the Study:

To identify specific neutrophil-binding peptides for targeted delivery.
To develop neutrophil-specific nanoparticles for therapeutic applications.
To investigate the modulation of neutrophil functions using targeted nanoparticles.

Main Methods:

Identification of peptides that specifically bind murine and human neutrophils.
Characterization of CD177 as a common neutrophil-expressed binding partner.
Decoration of nanoparticles with neutrophil-specific peptides for targeted accumulation at inflammation sites.
Encapsulation of neutrophil-modifying small molecules within targeted nanoparticles.

Main Results:

Neutrophil-specific peptides were identified, binding to CD177 in both species.
Neutrophil-specific nanoparticles effectively accumulated at inflammation sites.
Targeted nanoparticles precisely modulated neutrophil functions, including ROS production, degranulation, polarization, intracellular signaling, and longevity, both in vitro and in vivo.

Conclusions:

Neutrophil-specific targeting using peptide-decorated nanoparticles is feasible.
This approach enables precise modulation of neutrophil functions for therapeutic benefit.
Neutrophil-specific targeting represents a novel and powerful immunotherapeutic strategy for disease treatment.