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Published on: September 28, 2015
Immune and inflammatory mechanisms of abdominal aortic aneurysm
Ana Cristina Márquez-Sánchez1, Ekaterina K Koltsova1
1Department of Medicine, Department of Biomedical Sciences, Research Division in Immunology, Cedars-Sinai Cancer Institute, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Abstract:
Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and a destruction of the aortic wall during AAA development plays significant role in the pathogenesis of this disease. While various immune cells had been found in AAA, the mechanisms of their activation and function are still far from being understood. A better understanding of mechanisms regulating the development of aberrant immune cell activation in AAA is essential for the development of novel preventive and therapeutic approaches. In this review we summarize current knowledge about the role of immune cells in AAA and discuss how pathogenic immune cell activation is regulated in this disease.
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