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Updated: Aug 24, 2025

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Metal catalyzed C-H functionalization on triazole rings
Anushka Koranne1, Khushboo Kurrey1, Prashant Kumar1
1Govt. Shivnath Science College Gaurav Path Rajnandgaon 491441 Chhattisgarh India awadhbrave@gmail.com.
This review details C-H functionalization of triazole rings using palladium or copper catalysts. These methods enable the synthesis of diverse substituted 1,2,3- and 1,2,4-triazoles for various applications.
Area of Science:
- Organic Chemistry
- Catalysis
Background:
- Triazole rings are crucial scaffolds in medicinal chemistry and materials science.
- Efficient synthesis of substituted triazoles is essential for developing new pharmaceuticals and functional materials.
Purpose of the Study:
- To review recent advancements in C-H functionalization of triazole rings.
- To highlight synthetic strategies for accessing substituted 1,2,3- and 1,2,4-triazoles.
Main Methods:
- Utilizing palladium and copper catalysts for C-H functionalization reactions.
- Employing various organic substrates to achieve diverse triazole derivatives.
Main Results:
- Successful development of various substituted 1,2,3- and 1,2,4-triazoles.
- Demonstration of efficient C-H functionalization pathways on triazole cores.
Conclusions:
- C-H functionalization offers a powerful approach for synthesizing substituted triazoles.
- The reviewed methods are vital for pharmaceutical, medicinal, and materials chemistry applications.
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