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Primary urachal signet ring cell carcinoma: A case report
Qing Wang1, Xiaolong Chen1, Jianqing Zhang2
1Department of Urology, Guizhou Provincial People's Hospital, Guiyang, China.
This case report details a rare urachal signet ring cell carcinoma in a 49-year-old male. The aggressive tumor showed extensive metastasis, treated with surgery, chemotherapy, and targeted therapy, with the patient stable at 6 months.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Urachal signet ring cell carcinoma is an exceptionally rare and aggressive malignancy.
- Few documented cases exist, highlighting the need for further research and understanding.
Observation:
- A 49-year-old male presented with urinary frequency, pain during urination (urodynia), and hematuria.
- Diagnosis revealed primary urachal signet ring cell carcinoma with widespread metastases to the sigmoid colon, terminal ileum, mesentery, and peritoneum.
Findings:
- The patient underwent palliative surgery including partial cystectomy and en bloc resection of the urachus.
- Treatment involved a chemotherapy regimen of fluorouracil and cisplatin, alongside anlotinib for targeted therapy.
Implications:
- This case contributes to the limited literature on urachal signet ring cell carcinoma.
- Successful management with a multimodal approach (surgery, chemotherapy, targeted therapy) offers insights for similar rare cancer cases.
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