Current research and clinical trends in rosacea pathogenesis

Area of Science:

• Dermatology
• Inflammatory Skin Disorders
• Pathogenesis Research

Background:

• Rosacea is a common, complex chronic inflammatory skin disorder with unclear pathophysiology and etiology.
• Recent insights have significantly advanced the understanding of rosacea pathogenesis.
• A systematic analysis is needed to further research this condition.

Purpose of the Study:

• To establish an international core outcome and knowledge system for rosacea pathogenesis.
• To develop an analysis set for research and clinical studies on rosacea.
• Utilize bibliometric analysis and data mining for trend and hot spot identification.

Main Methods:

• Conducted a systematic search of WoS, PubMed, MEDLINE, Embase, and Cochrane databases.
• Performed visual bibliometric and data analysis on selected studies and outcomes.
• Utilized data mining techniques to identify trends and key areas.

Main Results:

• Analyzed 2,654 studies and 6,769 outcomes, revealing an increasing trend in rosacea research.
• Identified pathogenesis, risk factors, comorbidities, and therapeutic strategies as key research areas.
• Highlighted advancements in immunology, microorganisms, genetics, skin barriers, and neurogenetics, with a focus on immune and microbial factors.

Conclusions:

• Understanding of rosacea pathogenesis has improved due to technology and multidisciplinary integration.
• Further high-quality research is needed, particularly in genomic and neurogenic aspects.
• Integrating risk and comorbidity data is essential for guiding clinical practice.