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Cardiovascular Effects of COVID-19 - What Do We Know and Where Should We Go?
Matthew Ryan1, Ozan Demir1, Kevin O'Gallagher1
1School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research (NIHR) Biomedical Research Centre, King's College London, London, UK.
Insights
Understanding coronavirus disease 2019 (COVID-19)
Area of Science:
- Cardiology
- Infectious Diseases
- Vascular Biology
Background:
- The COVID-19 pandemic presents significant challenges, with a key focus on its cardiovascular implications.
- Research is exploring the role of cardiac biomarkers and imaging in assessing COVID-19 patient prognosis.
- The vascular endothelium's involvement in COVID-19 pathogenesis is under investigation.
Discussion:
- Early evidence suggests potential benefits of established cardiovascular disease treatments, including ACE inhibitors and primary angioplasty, for COVID-19 patients.
- The quality of current data is limited, necessitating further investigation.
- Key questions regarding COVID-19's cardiovascular effects require robust studies for definitive answers.
Key Insights:
- Cardiac biomarkers and imaging may aid in prognostic assessment for COVID-19 patients.
- Vascular endothelium dysfunction is implicated in the pathogenesis of COVID-19.
- Existing cardiovascular therapies show promise but require validation through rigorous trials.
Outlook:
- Further high-quality research is essential to clarify the cardiovascular impact of COVID-19.
- Well-designed studies will guide optimal therapeutic strategies for affected individuals.
- Understanding these mechanisms is crucial for managing the long-term cardiovascular consequences of COVID-19.
Abstract:
Amongst the many challenges of the global pandemic, understanding the effects of coronavirus disease 2019 (COVID-19) on the cardiovascular system has emerged as a key priority. Emerging data indicate possible roles for cardiac biomarkers and cardiac imaging in the prognostic assessment of these patients, as well as implications of the vascular endothelium in the pathogenesis of the condition. From a therapeutic perspective, early data suggest that the provision of well-established treatments for cardiovascular disease, whether with angiotensin-converting enzyme inhibitors or primary angioplasty, is likely to be beneficial. These early data are of limited quality however, and robust studies are needed to address many of the key remaining questions.
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