RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D

Area of Science:

• Structural Biology
• Bioinformatics
• Data Archiving

Background:

• The Protein Data Bank (PDB) has operated for over 50 years as a global archive for 3D biomolecular structures.
• It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership.
• The RCSB PDB serves as the US data center and Archive Keeper for the wwPDB.

Purpose of the Study:

• To describe the organization and functions of the RCSB PDB.
• To detail its collaboration with wwPDB partners in processing structural data depositions.
• To highlight the resources and tools available through RCSB.org and PDB101.RCSB.org for data exploration and education.

Main Methods:

• The RCSB PDB processes and archives 3D macromolecular structure data from various experimental methods (crystallography, NMR, EM, micro-ED).
• It utilizes the RCSB.org portal for public access, exploration, and 3D visualization of PDB data.
• The PDB101.RCSB.org portal is used for training, outreach, and educational initiatives.

Main Results:

• RCSB PDB manages a vast archive of 3D biomolecular structures, serving millions of data consumers globally.
• The RCSB.org portal offers unrestricted access to PDB data, featuring new tools for exploring structures relevant to cancer research.
• The PDB101.RCSB.org portal engages educators, students, and the public with structural biology information.

Conclusions:

• RCSB PDB plays a vital role in the global structural biology community by providing open-access data and educational resources.
• Its integrated approach to data archiving, dissemination, and education supports scientific advancement.
• The continuous development of tools and features enhances the utility of the PDB archive for diverse users.