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svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies.

Jonathan Pham1, Sofia Wyetzner2, Martin R Pfaller3

  • 1Department of Mechanical Engineering, Stanford University, Stanford, CA 94305.

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Summary

svMorph enables virtual sculpting of patient-specific vascular models, creating tortuosity, aneurysms, and stenoses. This framework aids in hemodynamic simulations and lumped-parameter model generation for research.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Computational Fluid Dynamics

Background:

  • Patient-specific vascular models are crucial for understanding hemodynamics.
  • Current methods for modifying vascular geometries can be complex and time-consuming.
  • Accurate simulation of vascular diseases requires precise anatomical modeling.

Purpose of the Study:

  • To introduce svMorph, an interactive framework for virtual sculpting of vascular anatomies.
  • To develop tools for creating tortuosity, aneurysms, and stenoses in vascular models.
  • To facilitate the generation of simulation-ready vascular models with altered geometries.

Main Methods:

  • svMorph utilizes geometric operations on surface meshes and centerline curves.
  • A physics-based Oriented Particles method with linear blend skinning is employed for tortuosity.
  • The framework integrates with existing vascular modeling software like simvascular.

Main Results:

  • Demonstrated the creation of diverse vascular shape changes in patient-specific models.
  • Performed 3D computational fluid dynamics (CFD) simulations to analyze hemodynamic effects.
  • Showcased automated generation of 0D lumped-parameter models for rapid hemodynamic estimation.

Conclusions:

  • svMorph provides a versatile platform for interactive modification of vascular geometries.
  • The framework supports the creation of anatomically accurate, simulation-suitable vascular models.
  • svMorph aids in studying the hemodynamic impact of vascular alterations and disease progression.