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Slice-direction geometric distortion evaluation and correction with reversed slice-select gradient acquisitions.

Anna I Blazejewska1, Thomas Witzel2, Jesper L R Andersson3

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.

Neuroimage
|October 25, 2022
PubMed
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Water/Fat Separated Echo Planar Time-Resolved Imaging (WFS-EPTI) for Distortion-Free Multi-Contrast MRI.

Magnetic resonance in medicine·2026

This study identifies and corrects slice direction geometric distortion in high-resolution 7 Tesla echo-planar imaging (EPI). A novel pulse sequence and gradient reversal method enable accurate spatial alignment of multi-contrast MRI data.

Area of Science:

  • Magnetic Resonance Imaging
  • Medical Physics
  • Neuroimaging

Background:

  • Accurate spatial alignment of multi-contrast MRI data is essential but challenging due to differing geometric distortions between acquisitions.
  • Single-shot echo-planar imaging (EPI) is susceptible to phase-encoding direction distortion from B0 field inhomogeneities.
  • High-resolution ultrahigh-field MRI (e.g., 7T) using low slice-encoding bandwidth can exhibit additional slice-direction geometric distortion.

Purpose of the Study:

  • To demonstrate and characterize slice-direction geometric distortion in high-resolution 7T EPI.
  • To introduce a novel pulse sequence for acquiring distortion-paired EPI data.
  • To validate a gradient reversal-based method for correcting slice-direction distortion.

Main Methods:

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  • Acquisition of 7T EPI data using a novel pulse sequence with reversible slice-encoding gradient polarity.
  • Acquisition of paired images with equal magnitude but opposite polarity slice-direction distortion.
  • Application of gradient reversal software, commonly used for phase-encoding distortion, to correct slice-direction distortion.

    • Main Results:

    • Demonstrated the presence of slice-direction geometric distortion in high-resolution 7T EPI.
    • Successfully acquired paired EPI images exhibiting symmetric slice-direction distortion with opposite polarity.
    • Showed that slice-direction distortion can be effectively corrected using the established gradient reversal method.

    Conclusions:

    • Slice-direction geometric distortion is a significant issue in high-resolution 7T EPI.
    • A novel pulse sequence enables the acquisition of data suitable for distortion correction.
    • Gradient reversal techniques can be effectively applied to correct slice-direction distortion, improving MRI data alignment.